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Author Owusu-Ansah, E. de-G.J.; Sampson, A.; Amponsah, S.K.; Abaidoo, R.C.; Dalsgaard, A.; Hald, T. doi  openurl
  Title Probabilistic quantitative microbial risk assessment model of norovirus from wastewater irrigated vegetables in Ghana using genome copies and fecal indicator ratio conversion for estimating exposure dose Type Journal Article
  Year 2017 Publication The Science of the total environment Abbreviated Journal Sci Total Environ  
  Volume 601-602 Issue Pages 1712-1719  
  Corporate Author Thesis  
  Address Genomic Epidemiology and Global Decision Support Initiative, National Food Institute, Soltofts Plads, Building 221 Room 250, Technical University of Denmark, 2800 Kgs Lyngby, Denmark  
  Keywords Disability Adjusted Life Years; Fecal indicator; Norovirus; Probabilistic model; Public health; Qmra  
  Abstract The need to replace the commonly applied fecal indicator conversions ratio (an assumption of 1:10(-5) virus to fecal indicator organism) in Quantitative Microbial Risk Assessment (QMRA) with models based on quantitative data on the virus of interest has gained prominence due to the different physical and environmental factors that might influence the reliability of using indicator organisms in microbial risk assessment. The challenges facing analytical studies on virus enumeration (genome copies or particles) have contributed to the already existing lack of data in QMRA modelling. This study attempts to fit a QMRA model to genome copies of norovirus data. The model estimates the risk of norovirus infection from the intake of vegetables irrigated with wastewater from different sources. The results were compared to the results of a corresponding model using the fecal indicator conversion ratio to estimate the norovirus count. In all scenarios of using different water sources, the application of the fecal indicator conversion ratio underestimated the norovirus disease burden, measured by the Disability Adjusted Life Years (DALYs), when compared to results using the genome copies norovirus data. In some cases the difference was >2 orders of magnitude. All scenarios using genome copies met the 10(-4) DALY per person per year for consumption of vegetables irrigated with wastewater, although these results are considered to be highly conservative risk estimates. The fecal indicator conversion ratio model of stream-water and drain-water sources of wastewater achieved the 10(-6) DALY per person per year threshold, which tends to indicate an underestimation of health risk when compared to using genome copies for estimating the dose.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (up) 0048-9697 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28618661 Approved no  
  Call Number NCSU @ edshirle @ Serial 3621  
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