NoroCORE Home

NoroCORE Food Virology Literature Database

Home |  Show All |  Simple Search |  Advanced Search

1–1 of 1 record found matching your query (RSS): Login

Select All    Deselect All << 1 >> print
  Record Links
Author Murphy, C.N.; Fowler, R.C.; Iwen, P.C.; Fey, P.D. doi  openurl
  Title (up) Evaluation of the BioFire FilmArray(R) GastrointestinalPanel in a Midwestern Academic Hospital Type Journal Article
  Year 2017 Publication European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Abbreviated Journal Eur J Clin Microbiol Infect Dis  
  Volume 36 Issue 4 Pages 747-754  
  Corporate Author Thesis  
  Address Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE, 68198-5900, USA  
  Keywords Academic Medical Centers; Bacterial Infections/*diagnosis/microbiology; Coinfection/*diagnosis/microbiology/virology; Diagnostic Tests, Routine/*methods; Gastroenteritis/*diagnosis/microbiology/virology; Hospitals; Humans; Microbiological Techniques/*methods; Midwestern United States; Virus Diseases/*diagnosis/virology  
  Abstract The BioFire FilmArray(R) Gastrointestinal Panel (GIP) was implemented to replace traditional stool culture and enzyme immunoassay (EIA) testing for stool pathogens. The purpose of this study was to evaluate the detection rate, incidence of coinfection, and culture recovery rate of gastrointestinal (GI) pathogens detected by the GIP over a 1-year period. A total of 2257 stools collected from January to December 2015 were tested using the GIP. Clostridium difficile colonization was also evaluated by an antigen/toxin EIA and confirmatory polymerase chain reaction (PCR). The GIP detected one pathogen in 911 (40.4%) specimens. Coinfections were detected in 176 (7.8%) of these specimens. The most frequently detected pathogens were C. difficile (15.2%), norovirus (8.9%), enteropathogenic Escherichia coli (7.1%), enteroaggregative E. coli (3.4%), Campylobacter spp. (2.3%), and sapovirus (2.0%). Each of the remaining GIP targets had a detection rate of </=1.6%. The recovery of bacteria for public health investigations varied, with rates as high as 77% for Salmonella to as low as 30% for Yersinia enterocolitica. Of stools positive for C. difficile on the GIP that were tested by EIA, only 42.7% (88/206) were found to be producing detectable toxin. Overall, the implementation of the GIP resulted in high detection rates of GI pathogens, including the frequent detection of coinfections. This is a promising test to streamline the testing of agents causing infectious gastroenteritis from multiple tests down to a single order with limited hands-on time. Ongoing studies will need to assess the impact that the GIP has on downstream patient care and public health practices.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0934-9723 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27957599 Approved no  
  Call Number NCSU @ edshirle @ Serial 3616  
Permanent link to this record
Select All    Deselect All << 1 >> print
Selected Records:    full entries      records per page
      using style:       sort by:       return as:  

Home Show All  |  Simple Search  |  Advanced Search  |  Library Search Fri, 18 Oct 2019
Help Show Record  |  Extract Citations 14:21:09 -0400