NoroCORE Home

NoroCORE Food Virology Literature Database

Home |  Show All |  Simple Search |  Advanced Search

1–1 of 1 record found matching your query (RSS): Login

Select All    Deselect All << 1 >> print
  Record Links
Author Lindesmith, L.C.; Mallory, M.L.; Jones, T.A.; Richardson, C.; Goodwin, R.R.; Baehner, F.; Mendelman, P.M.; Bargatze, R.F.; Baric, R.S. doi  openurl
  Title Impact of Pre-exposure History and Host Genetics on Antibody Avidity Following Norovirus Vaccination Type Randomized Controlled Trial
  Year (down) 2017 Publication The Journal of infectious diseases Abbreviated Journal J Infect Dis  
  Volume 215 Issue 6 Pages 984-991  
  Corporate Author Thesis  
  Address Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA  
  Keywords Adjuvants, Immunologic/administration & dosage; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing/blood; Antibodies, Viral/blood; *Antibody Affinity; Caliciviridae Infections/genetics/*prevention & control; Cross Reactions; Double-Blind Method; Epitopes/immunology; Female; Humans; Male; Middle Aged; Norovirus; United States; Vaccination; Vaccines, Virus-Like Particle/administration & dosage/*therapeutic use; Viral Vaccines/administration & dosage/*therapeutic use; Young Adult; *antibody; *avidity; *norovirus; *viral evolution; *enteric vaccine  
  Abstract Background: Development of high avidity, broadly neutralizing antibodies (Abs) is a priority after vaccination against rapidly evolving, widely disseminated viruses like human norovirus. After vaccination with a multivalent GI.1 and GII.4c norovirus virus-like particle (VLP) vaccine candidate adjuvanted with alum and monophosphoryl lipid A (MPL), blockade Ab titers peaked early, with no increase in titer following a second vaccine dose. Methods: Blockade Ab relative avidity was evaluated by measuring the slope of blockade Ab neutralization curves. Results: Blockade Ab avidity to the GI.1 vaccine component peaked at day 35 (7 days after dose 2). Avidities to heterotypic genogroup I VLPs were not sustained at day 35 after vaccination or GI.1 infection, as measured from archived sera. Only secretor-positive participants maintained high avidity blockade Ab to GI.1 at day 180. Avidity to the GII.4c vaccine component peaked at day 7, remained elevated through day 180, and was not secretor dependent. Avidity to an immunologically novel GII.4 strain VLP correlated with preexisting Ab titer to an ancestral strain Epitope A. Conclusions: Host genetics and pre-exposure history shape norovirus vaccine Ab responses, including blockade Ab avidity. Avidity of potentially neutralizing Ab may be an important metric for evaluating vaccine responses to highly penetrant viruses with cross-reactive serotypes.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-1899 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28453838 Approved no  
  Call Number NCSU @ edshirle @ Serial 3594  
Permanent link to this record
Select All    Deselect All << 1 >> print
Selected Records:    full entries      records per page
      using style:       sort by:       return as:  

Home Show All  |  Simple Search  |  Advanced Search  |  Library Search Sun, 18 Aug 2019
Help Show Record  |  Extract Citations 04:37:18 -0700