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Author Lee, H.; Ko, G.P. doi  openurl
  Title (up) New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota Type Journal Article
  Year 2017 Publication Gut microbes Abbreviated Journal Gut Microbes  
  Volume 8 Issue 6 Pages 616-620  
  Corporate Author Thesis  
  Address b Center for Human and Environmental Microbiome , Institute of Health and Environment, School of Public Health, Seoul National University , Seoul , Korea  
  Keywords IFN-beta; Lactobacillus; gut microbiome; norovirus; vitamin A  
  Abstract Gut microbiota has been revealed to play an important role in various health conditions, and recent studies have suggested the modulation of gut microbiota as a therapeutic strategy. There is no effective treatment of norovirus infection, though vitamin A has been suggested to have an antiviral effect in an epidemiological study. We demonstrated that vitamin A significantly inhibited murine norovirus replication. Vitamin A supplementation significantly increased the abundance of Lactobacillus sp. during norovirus infection, which played a crucial role in antiviral efficacy, inhibiting murine norovirus. Therefore, we elaborated the antiviral effect of vitamin A via modulation of gut microbiota. Furthermore, we suggest a novel strategy, using potential probiotics, as having a protective and therapeutic effect on noroviral infection.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1949-0976 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28727498 Approved no  
  Call Number NCSU @ edshirle @ Serial 3590  
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