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Author Kim, J.-H.; Park, J.-E.; Lin, M.; Kim, S.; Kim, G.-H.; Park, S.J.; Ko, G.P.; Nam, J.-M. doi  openurl
  Title Sensitive, Quantitative Naked-Eye Biodetection with Polyhedral Cu Nanoshells Type Journal Article
  Year (down) 2017 Publication Advanced materials (Deerfield Beach, Fla.) Abbreviated Journal Adv Mater  
  Volume 29 Issue 37 Pages  
  Corporate Author Thesis  
  Address Department of Chemistry, Seoul National University, Seoul, 08826, South Korea  
  Keywords Cu nanoshells; DNA detection; biosensors; naked-eye detection; norovirus  
  Abstract One of the most heavily used methods in chemical and biological labeling, detection, and imaging is based on silver shell-based enhancement on Au nanoparticles (AuNPs) that is useful for amplifying Rayleigh scattering, colorimetric signal, surface-enhanced Raman scattering, and electrical signal, but poor structural controllability and nonspecific growth of silver shells have limited its applications, especially with respect to signal reproducibility and quantification. Here, a highly specific, well-defined Cu nanopolyhedral shell overgrowth chemistry is developed with the aid of polyethyleneimine (PEI) on AuNPs, and the use of this PEI-mediated Cu polyhedral nanoshell (CuP) chemistry is shown as a means of light-scattering signal enhancement for the development of naked-eye-based highly sensitive and quantitative detections of DNA and viruses. Remarkably, these CuPs are exclusively formed on AuNPs in a controllable manner, with no noticeable nonspecific CuP growth. The findings enable to acquire clearly visible signals without analytic instrumentation, detectable down to 8 x 10(-15) m of DNA (anthrax sequence) and 2700 copies of viruses (noroviruses in clinical stool samples) with broad dynamic ranges on archetypal assay platforms. This new method provides a general platform in controlling Cu shell nanostructures and their optical signals, and opens up revenues for highly reliable, quantitative onsite naked-eye biodetection.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0935-9648 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28783216 Approved no  
  Call Number NCSU @ edshirle @ Serial 3581  
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