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Author Huang, X.-Y.; Su, J.; Lu, Q.-C.; Li, S.-Z.; Zhao, J.-Y.; Li, M.-L.; Li, Y.; Shen, X.-J.; Zhang, B.-F.; Wang, H.-F.; Mu, Y.-J.; Wu, S.-Y.; Du, Y.-H.; Liu, L.-C.; Chen, W.-J.; Klena, J.D.; Xu, B.-L. doi  openurl
  Title (up) A large outbreak of acute gastroenteritis caused by the human norovirus GII.17 strain at a university in Henan Province, China Type Journal Article
  Year 2017 Publication Infectious diseases of poverty Abbreviated Journal Infect Dis Poverty  
  Volume 6 Issue 1 Pages 6  
  Corporate Author Thesis  
  Address Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China. bianlixu@163.com  
  Keywords Acute Disease; Adult; China/epidemiology; Disease Outbreaks/*statistics & numerical data; Female; Gastroenteritis/*epidemiology/*virology; Humans; Male; Middle Aged; Norovirus/*genetics; Phylogeny; Universities; Young Adult; Acute gastroenteritis outbreak; China; Epidemiological investigation; Henan Province; Human norovirus; Phylogenetic analysis  
  Abstract BACKGROUND: Human noroviruses are a major cause of viral gastroenteritis and are the main etiological agents of acute gastroenteritis outbreaks. An increasing number of outbreaks and sporadic cases of norovirus have been reported in China in recent years. There was a large acute gastroenteritis outbreak at a university in Henan Province, China in the past five years. We want to identify the source, transmission routes of the outbreak by epidemiological investigation and laboratory testing in order to provide the effective control measures. METHODS: The clinical cases were investigated, and analysed by descriptive epidemiological methods according to factors such as time, department, grade and so on. Samples were collected from clinical cases, healthy persons, the environment, water, and food at the university. These samples were tested for potential bacteria and viruses. The samples that tested positive for norovirus were selected for whole genome sequencing and the sequences were then analysed. RESULTS: From 4 March to 3 April 2015, a total of 753 acute diarrhoea cases were reported at the university; the attack rate was 3.29%. The epidemic curve showed two peaks, with the main peak occurring between 10 and 20 March, accounting for 85.26% of reported cases. The rates of norovirus detection in samples from confirmed cases, people without symptoms, and environmental samples were 32.72%, 17.39%, and 9.17%, respectively. The phylogenetic analysis showed that the norovirus belonged to the genotype GII.17. CONCLUSIONS: This is the largest and most severe outbreak caused by genotype GII.17 norovirus in recent years in China. The GII.17 viruses displayed high epidemic activity and have become a dominant strain in China since the winter of 2014, having replaced the previously dominant GII.4 Sydney 2012 strain.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2049-9957 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28143569 Approved no  
  Call Number NCSU @ edshirle @ Serial 3565  
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