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Author (up) Cortes-Penfield, N.W.; Ramani, S.; Estes, M.K.; Atmar, R.L. doi  openurl
  Title Prospects and Challenges in the Development of a Norovirus Vaccine Type Journal Article
  Year 2017 Publication Clinical therapeutics Abbreviated Journal Clin Ther  
  Volume 39 Issue 8 Pages 1537-1549  
  Corporate Author Thesis  
  Address Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas. Electronic address:  
  Keywords Animals; Caliciviridae Infections/prevention & control; Humans; Norovirus/*immunology; *Viral Vaccines; acute gastroenteritis; calicivirus; norovirus; prevention; vaccine  
  Abstract PURPOSE: Norovirus is the leading cause of acute epidemic gastroenteritis among children under the age of 5 years and adults in the United States and in adults worldwide, accounting for an estimated 20% of episodes of acute gastroenteritis across all ages. No effective vaccine is presently available. This article provides an overview of the current state of norovirus vaccine development, emphasizing barriers and challenges in the development of an effective vaccine, correlates of protection used to assess vaccine efficacy, and the results of clinical trials of the major candidate vaccines. METHODS: We performed an unstructured literature review of published articles listed in PubMed in the field of norovirus vaccine development, with an emphasis on studies in humans. FINDINGS: Two candidate vaccines have reached clinical trials, and a number of other candidates are in the preclinical stages of development. Multivalent vaccination may be effective in inducing broadly neutralizing antibodies protective against challenge with novel and heterologous norovirus strains. Most identified correlates of protection have not been validated in large-scale challenge studies, nor have the degrees to which these correlates covary been assessed. IMPLICATIONS: Immune correlates of protection against norovirus infection need to be further developed to facilitate additional studies of the tolerability and efficacy of candidate norovirus vaccines in humans.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0149-2918 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28756066 Approved no  
  Call Number NCSU @ edshirle @ Serial 3525  
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