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Author (up) Ali, E.S.; Rajapaksha, H.; Carr, J.M.; Petrovsky, N. doi  openurl
  Title Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens Type Journal Article
  Year 2016 Publication Antiviral research Abbreviated Journal Antiviral Res  
  Volume 133 Issue Pages 14-22  
  Corporate Author Thesis  
  Address School of Medicine, Flinders University, Adelaide, South Australia, Australia; Vaxine Pty Ltd, Flinders Medical Centre/Flinders University, Adelaide, South Australia, Australia. Electronic address: nikolai.petrovsky@flinders.edu.au  
  Keywords Antiviral therapy; Binding inhibitors; Human histo-blood group antigen; Norovirus; Norovirus capsid proteins  
  Abstract Human noroviruses are the leading causative agents of epidemic and sporadic viral gastroenteritis and childhood diarrhoea worldwide. Human histo-blood group antigens (HBGA) serve as receptors for norovirus capsid protein attachment and play a critical role in infection. This makes HBGA-norovirus binding a promising target for drug development. Recently solved crystal structures of norovirus bound to HBGA have provided a structural basis for identification of potential anti-norovirus drugs and subsequently performed in silico and in vitro drug screens have identified compounds that block norovirus binding and may thereby serve as structural templates for design of therapeutic norovirus inhibitors. This review explores norovirus therapeutic options based on the strategy of blocking norovirus-HBGA binding.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0166-3542 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27421712 Approved no  
  Call Number NCSU @ edshirle @ Serial 3356  
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