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Author (up) Aliabadi, N.; Lopman, B.A.; Parashar, U.D.; Hall, A.J. doi  openurl
  Title Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations Type Journal Article
  Year 2015 Publication Expert review of vaccines Abbreviated Journal Expert Rev Vaccines  
  Volume 14 Issue 9 Pages 1241-1253  
  Corporate Author Thesis  
  Address Centers for Disease Control and Prevention, Division of Viral Diseases, Epidemiology Branch, Viral Gastroenterology Team, Atlanta, USA  
  Keywords Caliciviridae Infections/epidemiology/*prevention & control; Drug Discovery/trends; Gastroenteritis/epidemiology/*prevention & control/virology; Global Health; Health Services Needs and Demand; Humans; Norovirus/*immunology; Viral Vaccines/*immunology/*isolation & purification; Norwalk agent; calciviridae; epidemiology; gastroenteritis; norovirus; vaccine development  
  Abstract Human norovirus infection causes significant medical and financial costs in the USA and abroad. Some populations, including young children, the elderly, and the immunocompromised, are at heightened risk of infection with this virus and subsequent complications, while others, such as healthcare workers and food handlers are at increased risk of transmitting it, and some are at risk of both. Human noroviruses are heterogeneous with new strains emerging periodically. In addition to viral diversity, incompletely understood characteristics, such as virus-host cell binding and duration of immunity after infection add to the challenges of creating a norovirus vaccine. Although much progress has been made in recent years, many questions remain to be answered. In this review, we discuss the important areas and relevant literature in considering human norovirus vaccine development and potential targets for implementation.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1476-0584 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26224658 Approved no  
  Call Number NCSU @ edshirle @ Serial 3225  
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