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Author (up) Akasaka, T.; Shimizu-Onda, Y.; Hayakawa, S.; Ushijima, H. doi  openurl
  Title The virucidal effects against murine norovirus and feline calicivirus F4 as surrogates for human norovirus by the different additive concentrations of ethanol-based sanitizers Type Research Support, Non-U.S. Gov't
  Year 2016 Publication Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Abbreviated Journal J Infect Chemother  
  Volume 22 Issue 3 Pages 191-193  
  Corporate Author Thesis  
  Address Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan. Electronic address: ushijima-hiroshi@jcom.home.ne.jp  
  Keywords Ethanol-based sanitizer; Feline calicivirus; Human norovirus; Murine norovirus; Surrogate; Virucidal effect  
  Abstract Since human norovirus is non-cultivable, murine norovirus and feline calicivirus have been used as surrogates. In this study, the virucidal effects of ethanol-based sanitizers with different concentrations of additives (malic acid/sodium malate, glycerin-fatty acid ester) against murine norovirus and feline calicivirus F4 were examined. The ethanol-based sanitizers at pH 7 showed sufficient virucidal effects, but glycerin-fatty acid ester included in ethanol-based sanitizers at pH 4 or 6 reduced the virucidal effects against murine norovirus. The ethanol-based sanitizers containing malic acid/sodium malate inactivated feline calicivirus F4 in shorter time, but there is no difference between ethanol-based sanitizers with and without glycerin-fatty acid ester. Traditionally, feline calicivirus has been used for long time as a surrogate virus for human norovirus. However, this study suggested that murine norovirus and feline calicivirus F4 had different sensitivity with the additive components of ethanol-based sanitizers. Therefore, using feline calicivirus alone as a surrogate for human norovirus may not be sufficient to evaluate the virucidal effect of sanitizers on food-borne infections caused by human norovirus. Sanitizers having virucidal effects against at least both murine norovirus and feline calicivirus may be more suitable to inactivate human norovirus.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1341-321X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26482918 Approved no  
  Call Number NCSU @ edshirle @ Serial 3224  
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