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Author (up) Allen, D.J.; Adams, N.L.; Aladin, F.; Harris, J.P.; Brown, D.W.G. doi  openurl
  Title Emergence of the GII-4 Norovirus Sydney2012 strain in England, winter 2012-2013 Type Journal Article
  Year 2014 Publication PloS one Abbreviated Journal PLoS One  
  Volume 9 Issue 2 Pages e88978  
  Corporate Author Thesis  
  Address Virus Reference Department, Microbiology Services, Public Health England, London, United Kingdom  
  Keywords  
  Abstract Norovirus is the commonest cause of acute gastrointestinal disease and is the main aetiological agent of outbreaks of gastroenteritis, particularly in semi-closed environments. Norovirus infections in England typically peak between December and March each year. The most commonly detected norovirus strains belong to the genetically diverse genogroup-II genotype-4 (GII-4) genocluster and in the previous two norovirus winter seasons the majority of GII-4 strains in circulation worldwide have been genetically similar to the GII-4 strain New Orleans 1805/2009/USA. At the beginning of the 2012/13 season a genetically distinct GII-4 strain (Sydney 2012/NSW0514/2012/AU) was described which emerged worldwide during the winter of 2012/13. Here we describe the emergence of norovirus strains genetically related to Sydney2012 in England during the 2012/13 season to replace NewOrleans2009 strains as the most commonly detected variant of GII-4 norovirus in England. Furthermore, we demonstrate that whilst the emergence of Sydney2012 coincided with an early peak in the number of norovirus outbreaks, there was not an overall increase in norovirus activity compared to the previous season. Finally, we show that the Sydney2012 strain is associated with distinct genetic changes compared to the NewOrleans2009 strain, and these changes may have contributed to the emergence of the Sydney2012 strain.  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24551201 Approved no  
  Call Number NCSU @ edshirle @ Serial 2855  
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