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Author (up) Abugalia, M.; Cuevas, L.; Kirby, A.; Dove, W.; Nakagomi, O.; Nakagomi, T.; Kara, M.; Gweder, R.; Smeo, M.; Cunliffe, N. openurl 
  Title Clinical Features and Molecular Epidemiology of Rotavirus and Norovirus Infections in Libyan Children Type Journal Article
  Year 2011 Publication Journal of Medical Virology Abbreviated Journal  
  Volume 83 Issue 10 Pages 1849-1856  
  Corporate Author Thesis  
  Address [Kirby, A; Dove, W; Nakagomi, O; Nakagomi, T; Cunliffe, N] Univ Liverpool, Dept Clin Infect Microbiol & Immunol, Inst Infect & Global Hlth, Liverpool L69 3GA, Merseyside, England. [Abugalia, M; Smeo, M] Natl Ctr Dis Control, Tripoli, Libya. [Abugalia, M; Cuevas, L] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England. [Nakagomi, O; Nakagomi, T] Nagasaki Univ, Div Mol Epidemiol, Grad Sch Biomed Sci, Global Ctr Excellence, Nagasaki 852, Japan. [Kara, M; Gweder, R] Al Jala Childrens Hosp, Tripoli, Libya. Cunliffe, N (reprint author), Univ Liverpool, Dept Clin Infect Microbiol & Immunol, Inst Infect & Global Hlth, Duncan Bldg,Daulby St, Liverpool L69 3GA, Merseyside, England  
  Keywords rotavirus norovirus gastroenteritis genotypes Libya acute gastroenteritis global distribution intestinal disease relative frequency iraqi kurdistan acute diarrhea viral load strains vaccine burden  
  Abstract Rotaviruses and noroviruses are leading viral causes of diarrhoea in children. A cross-sectional study was undertaken among children aged <5 years with acute gastroenteritis at Al-Jala Children's Hospital, Tripoli, Libya, from October 2007 to September 2008. Of 1,090 fecal samples collected, 260 from inpatients and 830 from outpatients, all inpatients and approximately a third of outpatients, selected systematically, were investigated for rotavirus and norovirus infection by ELISA and real-time RTPCR, respectively. Of 520 fecal samples examined (inpatients = 260, outpatients = 260), 164 (31.5%) had rotavirus and 91(17.5%) had norovirus detected. Rotavirus was identified more often among inpatients than outpatients (35.8% vs. 27.3% respectively, P=0.038). Norovirus was detected more commonly among outpatients than inpatients (21.2% vs. 13.8% respectively, P=0.028). The peak incidence of infection with both viruses was among children aged between 6 and 11 months. The number of rotavirus cases was highest between November and June with a peak detection rate of 50% in January. Norovirus occurred most commonly from May through August with a peak detection rate of 47% in August. The most prevalent rotavirus genotypes were P[8], G9 In = 116, 65.9%), followed by P[8],G1 (n = 49, 27.8%); a single P[9], G3 strain was detected. There were seven distinct electropherotypes among the G9 strains and all belonged to VP7 Lineage III. Among 91 noroviruses identified, 90 were genogroup II. Of 26 genogroup II noroviruses examined, all were genotype GII.4. Rotaviruses and noroviruses are both important causes of gastrointestinal infection among young children in Libya. J. Med. Virol. 83:1849-1856, 2011. (C) 2011 Wiley-Liss, Inc.  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0146-6615 ISBN Medium  
  Area Expedition Conference  
  Notes ISI Document Delivery No.: 808NO Times Cited: 0 Cited Reference Count: 49 Abugalia, Mohamed Cuevas, Luis Kirby, Andrew Dove, Winifred Nakagomi, Osamu Nakagomi, Toyoko Kara, Majdi Gweder, Rabia Smeo, Mohamed Cunliffe, Nigel Libyan Ministry of Health and Libyan Cultural Affairs in London Grant sponsor: Libyan Ministry of Health and Libyan Cultural Affairs in London. Wiley-blackwell Malden Approved no  
  Call Number refbase @ user Serial 1877  
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